Healthy Joints

Healthy joints are essential to quality of life.

Running for a ball, getting up from a long nap or sitting for a treat, every move depends on healthy joints that move smoothly. The intricate structure of joints is remarkable and maintaining the health of joint components is key to long-term mobility.

Synovial Joints. The foundation of movement.

Synovial joints are the most common in a dog’s body and serve two functions: they enable movement and transfer weight distribution. For a joint to stay active, it must remain stable. Instability exerts abnormal forces on the joint and results in joint damage and disease progression.

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Anatomy of a Healthy Joint

Adequan Equine horse healthy joint graphic solo

Each component plays its part in mobility

Synovial Membrane is a specialized layer of connective tissue lining that secretes synovial fluid into the joint cavity to help maintain articular homeostasis.

Synovial (Joint) Fluid lubricates the joints and permits smooth movement. It also provides important nutrients to joints. It moves into the cartilage when the joint is resting and moves out into the joint space when the joint is active.

Articular Cartilage is the cushion within the joint that acts like a shock absorber. When healthy, it’s very smooth and has low friction, allowing bones in a joint to glide over each other during movement. This is where most joint disease manifests.1

Subchondral Bone is the layer of bone just below the cartilage; it absorbs the forces of movement and carries away waste from the joint. It contains sensory nerves and blood vessels.

The importance of preserving cartilage.

Unlike most tissues, cartilage contains no blood vessels, lymphatics or nerves. This unique and complex structure of articular cartilage gives it a limited capacity for healing and repair. It’s also subjected to the daily “wear and tear” of every movement. Damage to cartilage is associated with significant joint disease. Therefore, maintaining the health of articular cartilage is paramount to joint health.

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The healthy joint cycle for horses
Adequan® Canine brand of polysulfated glycosaminoglycan (PSGAG)
INDICATIONS Adequan® Canine is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.
IMPORTANT SAFETY INFORMATION Adequan® Canine should not be used in dogs who are hypersensitive to PSGAG or who have a known or suspected bleeding disorder. It should be used with caution in dogs with renal or hepatic impairment. Adverse reactions in clinical studies (transient pain at injection site, transient diarrhea, and abnormal bleeding) were mild and self-limiting. In post approval experience, death has been reported in some cases; vomiting, anorexia, depression/lethargy and diarrhea have also been reported. The safe use of PSGAG in breeding, pregnant or lactating dogs has not been evaluated. Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For additional safety information, please see Full Prescribing Information.
1. Clinician’s Brief, Aug 2013, Canine OA, DA Canapp, DVM, CCRT, CVA, DACVSMR.

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