Dog Owner FAQs

FOR DOG OWNER USE

Frequently asked questions about Adequan® Canine brand of polysulfated glycosaminoglycan (PSGAG)

Ask your veterinarian if Adequan® Canine is the right choice for your dog.


ABOUT ADEQUAN® CANINE

What is Adequan® Canine? Arrow Up
Adequan® Canine (polysulfated glycosaminoglycan) is the only FDA-approved disease-modifying osteoarthritis drug (DMOAD) for dogs. It is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints, also known as canine osteoarthritis (OA).
Are there age or breed restrictions for Adequan® Canine? Arrow Up
No age or breed restrictions.
Can Adequan® Canine be used in pregnant, breeding or lactating female dogs? Arrow Up
The use of Adequan® Canine in pregnant, breeding or lactating animals has not been evaluated.
How fast does Adequan® Canine work? Arrow Up
It begins to reach a dog’s joint synovial fluid within 2 hours and detectable levels are maintained in the synovial fluid and articular cartilage for up to 3 days (72 hours).1 Consult your veterinarian if you have any additional questions.




WHY USE ADEQUAN® CANINE

How is Adequan® Canine different from the non-steroidal anti-inflammatory drugs (NSAIDs)? Arrow Up
While NSAIDs are FDA approved drugs for use in dogs, none of the current non-steroidal anti-inflammatory drugs available today are approved as disease-modifying osteoarthritis drugs. They are only approved to help manage the pain associated with osteoarthritis inflammation. Adequan® Canine (polysulfated glycosaminoglycan) is a disease-modifying osteoarthritis drug (DMOAD) that modifies the course of the disease process.
Why did my veterinarian recommend treatment for my dog which only started showing clinical signs? Arrow Up
Adequan® Canine used early, at the first clinical signs of osteoarthritis, sometimes referred to as degenerative joint disease (DJD), slows progression of the disease before cartilage is irreversibly damaged. Adequan® Canine (polysulfated glycosaminoglycan) is the only FDA-approved disease-modifying osteoarthritis drug (DMOAD) that inhibits cartilage loss in a dog’s synovial joint, and may help to:2 Restore joint lubrication, relieve inflammation, and renew the building blocks of healthy cartilage.
How is Adequan® Canine different from products I can buy over the counter? Arrow Up
There are many supplements and over-the-counter products making similar claims to Adequan® Canine. These products and their manufacturing have not been evaluated by the FDA. Adequan® Canine (polysulfated glycosaminoglycan) is the only FDA-approved disease-modifying osteoarthritis drug for use in dogs and is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.




HOW TO USE

How can I learn whether Adequan® Canine may be right for my dog? Arrow Up
Consult your veterinarian on whether Adequan® Canine may be appropriate for your dog’s osteoarthritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
What is the treatment protocol for a dog starting with Adequan® Canine? Arrow Up
Consult your veterinarian on treatment protocol and whether Adequan® Canine may be an appropriate treatment for your dog.
The literature says use within 28 days and 10 puncture limit, how long past this can it be used? Arrow Up
Guidelines for usage are the following with whichever comes first: The expiration date printed on the bottle or within 28 days of the first puncture with a maximum of 10 punctures.
What is the 28-day expiration based on? Arrow Up
This is the guideline from the Center for Veterinary Medicine (CVM) division of the FDA (CVM GFI #242 In-Use Stability Studies and Associated Labeling Statements for Multiple-Dose Injectable Animal Drug Products, JANUARY 2017). This guideline applies to all veterinary injectable drugs packaged in multiple-dose vials.
I have an unopened vial that is expired, can I still use it? Arrow Up
American Regent, Inc. (the manufacturer of Adequan® Canine) does not recommend the use of expired products.
I have an opened vial that is not expired, but I haven’t used in a while, can I still use it? Arrow Up
Guidelines for usage are the following with whichever comes first: The expiration date printed on the bottle or within 28 days of first puncture with a maximum of 10 punctures. If the vial was opened/punctured more than 28 days ago, it is now expired, and usage is not recommended.
I have an open vial that is expired, but still has a lot of solution remaining, can I still use it? Arrow Up
American Regent, Inc. (the manufacturer of Adequan® Canine) does not recommend the use of expired product.
Can Adequan® Canine help all kinds of dogs? Arrow Up
While certain breeds are predisposed, canine osteoarthritis is common in all kinds of dogs, affecting younger dogs as well as older ones. Talk to your veterinarian. If you notice your dog slowing down or having trouble moving, ask your veterinarian if Adequan® Canine (polysulfated glycosaminoglycan) can help your dog.
My veterinarian has prescribed an alternate route of administration or regimen that differs from Adequan® Canine published information. What should I do? Arrow Up
Contact your veterinarian to discuss and confirm their guidance and direction.
Where do I administer the injection? Arrow Up
Contact your veterinarian to confirm and assist you.
The 4-week regimen was not finished, and a dose was missed, can the regimen just be restarted? Arrow Up
Please contact and consult with your veterinarian for continuing the use of Adequan® Canine in your dog.
Do I have to keep Adequan® Canine refrigerated? Arrow Up
No, Adequan® Canine (polysulfated glycosaminoglycan) needs to be stored at 68° to 77° F (20° to 25° C) with excursions permitted to 59° to 86° F (15° to 30° C). Avoid prolonged exposure to temperatures greater or equal to 104° F (40° C).
My veterinarian provided storage information that differs from the Adequan® Canine published information, what should I do? Arrow Up
Contact your veterinarian to discuss and confirm their guidance and direction.
If Adequan® Canine product was shipped in a method different from the recommended storage, what should I do? Arrow Up
Contact your on-line pharmacy or the veterinary clinic providing the product.




SAFETY INFORMATION

Any Precautions? Arrow Up
The safe use of Adequan® Canine (polysulfated glycosaminoglycan) used in breeding, pregnant, or lactating dogs has not been evaluated. Use with caution in dogs with renal or hepatic impairment.
What is the current Important Safety Information (ISI)? Arrow Up



FOR MORE INFORMATION

Who can I call with questions about Adequan® Canine? Arrow Up
First, we would suggest you consult your veterinarian. If you would like to speak to an American Regent Animal Health customer service representative, please call 800-458-0163 Monday-Thursday from 8:30 a.m. to 6:00 p.m. ET or Friday from 8:30 a.m. to 5:00 p.m. ET.
Need assistance or want more details? Arrow Up
Please go to Contact Us or explore the information on this site. Learn more
Adequan® Canine brand of polysulfated glycosaminoglycan (PSGAG)
INDICATIONS Adequan® Canine is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.
IMPORTANT SAFETY INFORMATION Adequan® Canine should not be used in dogs who are hypersensitive to PSGAG or who have a known or suspected bleeding disorder. It should be used with caution in dogs with renal or hepatic impairment. Adverse reactions in clinical studies (transient pain at injection site, transient diarrhea, and abnormal bleeding) were mild and self-limiting. In post approval experience, death has been reported in some cases; vomiting, anorexia, depression/lethargy and diarrhea have also been reported. The safe use of PSGAG in breeding, pregnant or lactating dogs has not been evaluated. Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For additional safety information, please see Full Prescribing Information.
1. Adequan® Canine (polysulfated glycosaminoglycan) NADA 141-038 FOI Summary, 1997.
2. Adequan® Canine Package Insert, Rev. 1/19.

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