Veterinarian FAQs

FOR PRESCRIBING VETERINARIANS.

Frequently asked questions about Adequan® Canine brand of polysulfated glycosaminoglycan (PSGAG)

ABOUT ADEQUAN® CANINE

What is Adequan® Canine? Arrow Up
Adequan® Canine (polysulfated glycosaminoglycan) is the only FDA-approved disease-modifying osteoarthritis drug (DMOAD) for dogs. It is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.
How is Adequan® Canine different from a non-steroidal anti-inflammatory drug (NSAID)? Arrow Up
Adequan® Canine is a prescription formulation PSGAG. It is a disease-modifying osteoarthritis drug (DMOAD) which inhibits cartilage loss in a dog’s joints. The specific mechanism of action of Adequan® in canine joints is not known.1
How is Adequan® Canine packaged? Arrow Up
Adequan® Canine Solution is supplied as 100 mg/mL in a 5 mL preserved multiple dose vial; packaged 2 vials per box.
What is the dosage and administration? Arrow Up
2 mg/lb body weight (0.02 mL/lb or 1 mL/50 lb) by intramuscular (IM) injection only, twice weekly for up to 4 weeks (maximum of 8 injections). Do not exceed the recommended dose or therapeutic regimen.
How fast does Adequan® Canine work? Arrow Up
It begins to reach joint synovial fluid within 2 hours and detectable levels are maintained in the synovial fluid and articular cartilage for up to 3 days (72 hours).2
Are there age or breed restrictions for Adequan® Canine? Arrow Up
No age or breed restrictions.
Can Adequan® Canine be used in pregnant, breeding or lactating female dogs? Arrow Up
The use of Adequan® Canine in pregnant, breeding or lactating animals has not been evaluated.
What is the pharmacology of Adequan® Canine? Arrow Up
  • Low molecular weight allows the distribution of PSGAG from the bloodstream to the synovial fluid.
  • PSGAG reaches synovial fluid within 2 hours of injection.2
  • Distribution from the synovial fluid to the cartilage takes place by diffusion.
  • In the articular cartilage, the drug is deposited into the cartilage matrix.
  • Detectable levels are maintained in synovial fluid and articular cartilage for up to 72 hours.2
  • The specific mechanism of action of Adequan® Canine in canine joints is not known.




MODE OF ACTION & EFFICACY

What is the Mechanism of Action for Adequan® Canine? Arrow Up
The specific mechanism of action of Adequan® in canine joints is not known.1 In vitro research suggests PSGAG:1
  • Inhibits certain catabolic enzymes which have increased activity in inflamed joints.
  • Enhances the activity of anabolic enzymes.
  • Anabolic effects studied include the ability to stimulate the synthesis of protein, collagen and proteoglycans.
  • Potentiates hyaluronic acid synthesis by synovial membrane cells (synoviocytes)
  • In the articular cartilage the drug is deposited into cartilage matrix and may help shield against further degradation.
What is the proof of efficacy for Adequan® Canine? Arrow Up



HOW TO USE: PROTOCOL

Can I give Adequan® Canine to a dog already taking an NSAID? Arrow Up
American Regent Animal Health (ARAH) has not completed any trials or studies identifying the combination use of NSAIDs and Adequan® Canine (polysulfated glycosaminoglycan).
What is the treatment protocol for a new patient starting with Adequan® Canine? Arrow Up
The approved label dose of Adequan® Canine is 2 mg/lb body weight (0.02 mL/lb or 1 mL/50 lb), by intramuscular injection only, twice weekly for up to 4 weeks (maximum of 8 injections). Repeat this treatment protocol as needed. Do not exceed the recommended dose or therapeutic regimen. Do not mix Adequan® Canine with other drugs or solvents. Be sure to practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the stopper prior to entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once. Use within 28 days of first puncture and puncture a maximum of 10 times. Dispose of spent needles in accordance with all federal, state and local environmental laws.
What is the treatment protocol after the first 8 injections? Arrow Up
The approved label dose of Adequan® Canine is 2 mg/lb body weight (0.02 mL/lb or 1 mL per 50 lb), by intramuscular injection only, twice weekly for up to 4 weeks (maximum of 8 injections). We have no further studies or technical data supporting a use protocol beyond the approved label dosing.
Where do I administer an injection? Arrow Up
Intramuscular (IM) administration should be in a major muscle group.
Can the 8 doses be withdrawn at one time for a full course of treatment into 8 syringes to have available for traveling? Arrow Up
No, there has been no stability testing of Adequan® Canine when stored in a syringe and this is not recommended. Each dose should be drawn into a syringe and used immediately.
Do I have to keep Adequan® Canine refrigerated? Arrow Up
No, Adequan® Canine needs to be stored at 68° to 77° F (20° to 25° C) with excursions permitted to 59° to 86° F (15° to 30° C). Avoid prolonged exposure to temperatures greater or equal to 104° F (40° C).
Is Adequan® Canine in a multiple-use vial? Arrow Up
Yes, Adequan® Canine contains a preservative, which allows for multiple punctures of an individual vial. Adequan® Canine must be used within 28 days of first puncture and is limited to a maximum puncture of 10 times. Please properly dispose of spent needles in accordance with all federal, state and local environmental laws.




HOW DOES ADEQUAN® CANINE COMPARE?

What is the difference between FDA-approved prescription Adequan® Canine and other over-the-counter products? Arrow Up
There are many supplements and over-the-counter products making similar claims to Adequan® Canine. However, these products do not have the structured and qualified product testing and trials Adequan® Canine completed to obtain FDA-approval. Adequan® Canine (polysulfated glycosaminoglycan) is the only FDA-approved disease-modifying osteoarthritis drug for use in dogs and is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.




SAFETY INFORMATION

Are there any Contraindications? Arrow Up
Do not use in dogs showing a hypersensitivity to PSGAG. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders.
Any Precautions? Arrow Up
The safe use of Adequan® Canine used in breeding, pregnant, or lactating dogs has not been evaluated. Use with caution in dogs with renal or hepatic impairment.
What is the current Important Safety Information (ISI)? Arrow Up



ABOUT AMERICAN REGENT ANIMAL HEALTH (ARAH)

Who is American Regent Animal Health? Arrow Up
American Regent Animal Health is committed to advancing animal health with proven FDA-approved products like Adequan® branded products. The company’s portfolio is anchored by the only FDA-approved polysulfated glycosaminoglycan products for horses and dogs. For more than 20 years, Adequan® Canine (polysulfated glycosaminoglycan) has been prescribed by veterinarians across the country and helped thousands of dogs lead more active lives. Until recently, Adequan® Canine was marketed under a licensing agreement by another animal health company. In 2018, American Regent Animal Health brought Adequan® Canine back into its portfolio, signaling its renewed commitment to animal health and this long-standing brand.
Where can I find out more about American Regent Animal Health? Arrow Up



HOW TO PURCHASE

How can I order Adequan® Canine? Arrow Up
Your Adequan® Canine needs can be serviced through a wide network of authorized veterinary distributors. Please visit Ordering Information or call ARAH at 800-458-0163.
Can veterinarians or pet owners purchase Adequan® Canine directly from American Regent Animal Health? Arrow Up
We have established a wide network of distributors that make purchase easy. Veterinarians that want to buy directly from ARAH should contact our National Key Accounts Manager to discuss available options. As this is a prescription-only product, pet owners must purchase through a licensed, practicing veterinarian.
Product was shipped in a method differing from the recommended storage, what should I do? Arrow Up
Contact your distributor.
How do I return expired product? Arrow Up
Short-dated or expired Adequan® Canine product should be returned to the distributor that originally supplied the product, per their established return policies. Contact your distributor or American Regent Animal Health at 800-458-0163.
Do I have an ARAH sales representative I can call? Arrow Up Which distributors currently carry Adequan® Canine? Arrow Up




FOR MORE INFORMATION

Where can I get marketing and in-clinic material? Arrow Up Who can I call with questions about Adequan® Canine? Arrow Up
To speak to a customer service representative, please call 800-458-0163 Monday-Thursday from 8:30 a.m. to 6:00 p.m. ET and Friday from 8:30 a.m. to 5:00 p.m. ET or email cs@americanregent.com. For technical questions, please call Medical Affairs at 888-354-4855 Monday-Friday, 9 a.m. to 5 p.m. ET. To report an adverse event, call 800-734-9236 or email pv@americanregent.com.
Adequan® Canine brand of polysulfated glycosaminoglycan (PSGAG)
INDICATIONS Adequan® Canine is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.
IMPORTANT SAFETY INFORMATION Adequan® Canine should not be used in dogs who are hypersensitive to PSGAG or who have a known or suspected bleeding disorder. It should be used with caution in dogs with renal or hepatic impairment. Adverse reactions in clinical studies (transient pain at injection site, transient diarrhea, and abnormal bleeding) were mild and self-limiting. In post approval experience, death has been reported in some cases; vomiting, anorexia, depression/lethargy and diarrhea have also been reported. The safe use of PSGAG in breeding, pregnant or lactating dogs has not been evaluated. Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For additional safety information, please see Full Prescribing Information.
1. Adequan® Canine Package Insert, Rev. 1/19.
2. Adequan® Canine (polysulfated glycosaminoglycan) NADA 141-038 FOI Summary, 1997.

Let’s stay in touch.

Be the first to hear about important news and product information!
First, select the one that best describes you.
Then we'll take you to our sign-up page.

CANINE VETERINARY
PROFESSIONAL
DOG OWNER
AMERICAN REGENT ANIMAL HEALTH
About Us Our Brands